Drug Uses

Valtrex is indicated for the treatment of herpes zoster (shingles), for the treatment or suppression of genital herpes in immunocompetent individuals and for the suppression of recurrent genital herpes in HIV-infected individuals and is also indicated for the treatment of cold sores (herpes labialis).

How Taken

Valtrex comes as a tablet to take it orally. It is usually taken every 8 hours (three times a day) for 7 days to treat shingles. To treat genital herpes it is usually taken twice a day for 5 days. For cold sores, Valtrex is usually taken for one day only. Do not take more or less of it or take it more often than prescribed by your doctor. Use this medication as soon as possible after symptoms appear. Continue to take Valtrex even if you feel well. Do not stop taking Valtrex without talking to your doctor.

Warnings/Precautions

Do not take Valtrex without first talking to your doctor if you are allergic to acyclovir (Zovirax). Before taking this medication, tell your doctor if you have kidney disease or immune system problems. You may need a dosage adjustment or special monitoring during treatment with Valtrex. Valtrex is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Valtrex passes into breast milk and how it may affect a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you miss a dose of Valtrex, take it as soon as you remember and then take your next dose at its regular time. However, if it is almost time for your next dose, do not take the missed dose. Wait and take the next dose at the regular time.

Possible Side Effects

Kidney failure and nervous system problems are not common, but can be serious in some patients taking Valtrex. Nervous system problems include aggressive behavior, unsteady movement, shaky movements, confusion, speech problems, hallucinations (seeing or hearing things that are really not there), seizures, and coma. Kidney failure and nervous system problems have happened in patients who already have kidney disease and in elderly patients whose kidneys do not work well due to age. Always tell your healthcare provider if you have kidney problems before taking Valtrex. Call your doctor right away if you get a nervous system problem while you are taking Valtrex. Common side effects of Valtrex include headache, nausea, stomach pain, vomiting, and dizziness. Side effects in HIV-infected adults include headache, tiredness, and rash. These side effects are usually mild and usually do not cause patients to stop taking Valtrex. Other less common side effects include painful periods in women, joint pain, depression, low blood cell counts, and changes in tests that measure how well the liver and kidneys work.

Storage

Store at 15° to 25°C (59° to 77°F).Keep Valtrex a tightly closed container. Do not keep medicine that is out of date or that you no longer need. Keep Valtrex and all medicines out of the reach of children.

Overdose

Seek emergency medical treatment if an overdose is suspected. The symptoms of an overdose of Valtrex are not well known, but an overdose of acyclovir (Zovirax), which is a similar drug, may cause seizures, hallucinations, and kidney damage (decreased urine production).

More Information

Herpes infections are contagious and you can infect other people, even during treatment. Avoid letting infected areas come into contact with other people. Wash your hands frequently to prevent transmission. Valtrex will not prevent the spread of genital herpes. Avoidance of sexual intercourse and use of latex condoms may prevent spreading the virus to others.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Herpes infections down, but still are a concern
CHICAGO - Nearly 25 years after a news magazine declared that an epidemic of genital herpes threatened to undo the sexual revolution, a new study finds an encouraging decline in the percentage of people infected with the herpes virus.
Back in 1982, a Time cover story headlined “The New Scarlet Letter” sounded an alarm that seems mild now compared to concern over another sexually transmitted lifetime infection, the AIDS virus.
The new study shows a 19 percent drop since 1994 in the percentage of Americans ages 14 to 49 testing positive for herpes type 2, the most common cause of the recurring painful sores of genital herpes. The declines were especially pronounced among young people.
The findings, appearing in Wednesday’s Journal of the American Medical Association, represent biological evidence of a decrease in risky sexual behavior among adolescents, said lead author Dr. Fujie Xu of the Centers for Disease Control and Prevention.
“Overall, this is good news. There is a decrease occurring among all youth, males and females, and in all racial groups,” Xu said. “That’s very encouraging.”
But herpes is still uncomfortably common. Despite the decline, blood tests of more than 11,000 people found 11 percent of men and 23 percent of women carry the genital herpes, or type 2, virus. Among people in their 20s, the infection rate was almost 11 percent.
Ironically, the rates have dropped back to about where they were when Time ran its cover story, said study co-author Dr. Stuart Berman of the CDC.
“If it was a scarlet letter then, I don’t know what you call it now and there’s more HIV around,” Berman said. Herpes greatly increases the chances of infection with HIV, the virus that causes AIDS.
“It’s still an epidemic,” said Dr. Tom Cherpes of the University of Pittsburgh School of Medicine, who was not involved with the study. “The fact that there’s a trend downward should not be construed by anybody that herpes is under control.”
In addition, 56 percent of men and 60 percent of women tested positive for the oral herpes virus, type 1, which is best known as the culprit behind cold sores, but can spread to the genitals through oral sex. Type 1 may be causing more genital infections in some groups, such as college students, Xu and Berman said.
Herpes can be treated with antiviral drugs, which can help prevent flare-ups and reduce the risk of spreading it to others. Condoms can help lower the risk of transmission, although they’re not foolproof. Infected people are contagious even without symptoms.
The study was funded by the CDC. A previous CDC report in 1997 found a 30 percent increase in herpes infection since the late 1970s.
“This new data really reverses the trend,” said study co-author Francis Lee of Emory University.
Dr. Kenneth Fife of the Indiana University School of Medicine, who was not involved in the study, noted that rates of infection are still disproportionately high among women and blacks. The study found 42 percent of blacks tested positive for herpes type 2, a decline of only 4 percent since 1994.
“Maybe we’ve finally gotten through to the young people that they need to change their behavior,” Fife said. “We still see plenty of genital herpes. There are adolescents who are becoming infected.”

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