Drug Uses

Penlac is an antifungal indicated as topical treatment for onychomycosis of fingernails and toenails.

How Taken

Before you start applying Penlac, remove any loose nail or nail material using nail clippers or nail files. Apply Penlac once daily (preferably at bedtime) to all affected nails with the applicator brush provided. Apply the lacquer evenly over the entire nail. Allow the lacquer to dry (approximately 30 seconds) before putting on socks or stockings. After applying this medication, wait 8 hours before taking a bath or shower.

Warnings/Precautions

Use Penlac only on nails and immediately adjacent skin. Avoid contact with the eyes and mouth.

Missed Dose

Apply Penlac as soon as you remember.

Possible Side Effects

The most common adverse reactions are rash-related. Inform your health care professional if the area of application shows signs of increased irritation (redness, itching, burning, blistering, swelling, oozing)

Storage

Store Penlac at room temperature between 59° and 86° F (15° and 30° C). Keep out of the reach of children.

Overdose

Overdoses are highly unlikely to occur. Seek medical attention if you suspect an overdose.

More Information

Do not use nail polish or other nail cosmetic products on the treated nails. Avoid use near heat or open flame, because product is flammable.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Smokers' Skin Is More Wrinkled, Even In Areas Shielded From Sunlight
Science Daily — In classic movies, cigarette smoking was used as shorthand to convey sultriness and beauty. In the real world, the connection between smoking and one's appearance -- as many studies have shown -- has more to do with premature signs of aging and less to do with glamour and refinement.
A new study from the University of Michigan Health System adds another dimension to the link between cigarette smoking and skin damage. The study suggests that smoking may be associated with a higher degree of aging on areas of skin, such as that of the inside of the upper arm, that are not normally exposed to sunlight.
"We examined non-facial skin that was protected from the sun, and found that the total number of packs of cigarettes smoked per day and the total years a person has smoked were linked with the amount of skin damage a person experienced," says Yolanda R. Helfrich, M.D., lead author and assistant professor of dermatology at the U-M Medical School.
The researchers developed a photonumeric scale that can be easily reproduced by other medical institutions to measure the degree of aging on patients' skin. The nine-point scale used information from photographs of the inside-upper-arm skin of the 77 participants.
Two medical residents and a medical student were asked to look at the photographs and assign a grade in which zero represented no fine wrinkling and eight represented severe fine wrinkling. The same three people reviewed photos of the participants one year later, and the scores were used to determine the level of increase in the skin damage.
Researchers also collected data about the participants from interviews, such as their age, ethnicity, history of cigarette smoking, use of non-steroidal anti-inflammatory drugs, use of dietary or herbal supplements, sun exposure, sunscreen use, tanning bed use and, for women, how many children they had given birth to, hormone therapy use and oral contraceptive use.
Among the people in the study who were current or former smokers, they had smoked an average of about 24 years. In all, among participants who were 45 years or older, the degree of skin aging was found to be significantly higher in smokers than nonsmokers.
In the 45-65 age group, smokers had an average score on the photonumeric scale of more than two, while nonsmokers had an average score of less than one. In the 65 and older age group, smokers had an average score of about six, while nonsmokers had an average score of approximately four.
In addition to Helfrich, authors were Abena Ofori, M.D.; Ted A. Hamilton, M.S.; Jennifer Lambert, M.S.; Anya King, M.P.H.; John J. Voorhees, M.D.; and senior author Sewon Kang, M.D., all of the U-M Department of Dermatology; and Le Yu, M.D., now with Cedars Sinai Medical Center in Los Angeles.

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