Drug Uses

Paxil is an agent in a newer class of antidepressant medication known as selective serotonin reuptake inhibitors (SSRIs). Depression and anxiety disorders might be caused by a chemical imbalance in the brain. One of these chemicals is serotonin, which helps send electrical signals from one nerve cell to another. In the process, serotonin is released from one nerve cell (the sender) and travels to the next (the receiver), where it is either absorbed or returns back to the original sender cell.

How Taken

Paxil comes as a tablet to take it orally. It is usually taken once daily and may be taken with or without food. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take Paxil even if you feel well. Do not stop taking Paxil without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Warnings/Precautions

Before taking Paxil, tell your doctor if you have liver disease, kidney disease, seizures or epilepsy, or a manic disorder or suicidal thoughts. You may not be able to take Paxil, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Paxil is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take Paxil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Paxil passes into breast milk and may affect a nursing baby. Do not take Paxil without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

If you experience any of the following serious side effects, stop taking Paxil and contact your doctor immediately or seek emergency medical treatment: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); an irregular heartbeat or pulse; low blood pressure (dizziness, weakness); high blood pressure (severe headache, blurred vision); unusual bleeding or bruising; or fever or chills. Less serious side effects may be more likely to occur. Continue to take Paxil and talk to your doctor if you experience headache; tremor, nervousness, or anxiety; nausea, diarrhea, dry mouth, or changes in appetite or weight; sleepiness or insomnia; or decreased sex drive, impotence, or difficulty having an orgasm. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store at controlled room temperature between 20-25°C (68-77°F).

Overdose

Seek emergency medical attention if an overdose is suspected. Symptoms of a Paxil overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

More Information

Use caution when driving, operating machinery, or performing other hazardous activities. Paxil may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking Paxil.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Can anti-depressants interfere with tamoxifen treatment for breast cancer?
Many different drugs are used to treat depression. One family of drugs that are often used are the SSRIs (selective serotonin reuptake inhibitors). These drugs may also be used to treat hot flushes caused by hormonal treatments like tamoxifen.
Some studies have looked at the effect of taking an SSRI drug at the same time as tamoxifen. These show that taking an SSRI can change the way the body handles tamoxifen (tamoxifen metabolism).
Not all SSRIs affect tamoxifen metabolism equally. Paroxetine (Seroxat) and fluoxetine (Prozac) have the strongest effect, and the drugs citalopram (Cipramil) and venlafaxine (Efexor) have a weaker effect.
No one is sure if these changes in tamoxifen metabolism affect how well it works as a breast cancer treatment. We don’t know whether taking an SSRI makes tamoxifen less effective. More studies are being done to look into this.
If you are taking an SSRI and are also taking tamoxifen then have a chat with your doctor. They will be able to talk through the best options for you. These may include:
* Continuing with your present treatment
* Changing to one of the SSRI tablets that seems to have smaller effect on tamoxifen metabolism
* Stopping the SSRI and taking another treatment for depression or hormonal symptoms
* Changing to another hormone treatment not affected by SSRIs and continuing with the anti-depressant.

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