Drug Uses

Fosamax is indicated for treatment and prevention of osteoporosis in postmenopausal women. For the treatment of osteoporosis, Fosamax increases bone mass and reduces the incidence of fractures, including those of the hip and spine. It is also indicated for the prevention of osteoporosis, treatment to increase bone mass in men with osteoporosis, treatment of glucocorticoid. It is used to treat induced osteoporosis in men and women receiving glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density, treatment of Paget's disease of bone in men and women.

How Taken

Fosamax comes as a tablet to take by mouth. It should be taken once a day in the morning on an empty stomach. Fosamax should be taken with a full glass (6-8 ounces) of plain water. Wait at least 30 minutes after taking Fosamax before you eat, drink, or take other medications. Do not take Fosamax with mineral water, coffee, orange juice, milk, or other dairy products. Do not suck or chew the tablet; swallow the tablet whole. Do not lie down for at least 30 minutes after taking Fosamax. Standing or sitting upright helps you get the full dose and decreases heartburn or the risk of injury to your esophagus.

Warnings/Precautions

Before taking Fosamax, tell your doctor if you have a problem swallowing, such as a narrowing of the esophagus; have esophageal ulcers or an esophageal disease; have a condition that causes low levels of calcium in the body; have kidney disease; have stomach ulcers or other stomach or digestive problems; or are unable to stand or sit upright for at least 30 minutes. You may not be able to take Fosamax, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Fosamax is in the FDA pregnancy category C. This means that it is not known whether Fosamax will be harmful to an unborn baby. Do not take Fosamax without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Fosamax passes into breast milk. Do not take Fosamax without first talking to your doctor if you are breast-feeding a baby.

Missed Dose

If you take Fosamax every day and you miss a dose, skip that dose and take the next regularly scheduled dose the following day. Missing one dose will not affect your treatment. Do not take two tablets at the same time. If you take a Fosamax once a week and you miss a dose, take the missed dose on the morning after you remember. Do not take two tablets on the same day. Return to taking one tablet once a week, as originally scheduled on your chosen day.

Possible Side Effects

Stop taking Fosamax if you experience any of the following serious side effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); Seek emergency or talk to your doctor if you have difficulty or pain when swallowing; chest pain; pain or burning under the ribs or in the back; or new or worsening heartburn. Other, less serious side effects may be more likely to occur. Continue to take Fosamax and talk to your doctor if you experience abdominal discomfort; stomach upset, nausea, vomiting, diarrhea, or constipation; headache; muscle, bone, or joint soreness or aches; eye pain; a rash; or an altered sense of taste. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store in a well-closed container at room temperature, 15-30°C (59-86°F).

Overdose

Hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, heartburn, esophagitis, gastritis, or ulcer, may result from oral over dosage. If you do think that an overdose has occurred, call an emergency room or poison control center.

More Information

Follow you doctor's recommendations about drinking alcohol and smoking. These activities are related to decreased bone density. Antacids and other medicines taken by mouth may decrease the effects of Fosamax. Do not take any other medicines within 30 minutes after a dose of Fosamax. Talk to your doctor before taking any other medicines during treatment with Fosamax.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Breast Cancer Getting the facts about breast cancer and mammograms is an important step in taking care of your health. This pamphlet will help you to get the information that you need. It provides information on a woman's risk for breast cancer, the National Cancer Institute's recommendations about mammograms, and the benefits and limitations of the procedure. After skin cancer, breast cancer is the most frequently diagnosed cancer in women in the United States. It is second only to lung cancer in cancer-related deaths. Approximately 180,000 new cases of breast cancer are estimated for 1997, and about 44,000 women are expected to die from the disease. Who Is at Risk for Breast Cancer? Simply being a woman and getting older puts you at some risk for breast cancer. Your risk for breast cancer continues to increase over your lifetime. Several known factors can further increase your risk for breast cancer. Most women who get breast cancer have no known risk factors such as a family history of the disease. Talk to your doctor about the known risk factors for breast cancer. What factors can increase your risk for breast cancer? One or more of the following conditions place a woman at higher than average risk for breast cancer: personal history of a prior breast cancer evidence of a specific genetic change that increases susceptibility to breast cancer (BRCA1/BRCA2 mutations) mother, sister, daughter, or two or more close relatives, such as cousins, with a history of breast cancer (especially if diagnosed at a young age) a diagnosis of a breast condition (i.e., atypical hyperplasia) that may predispose a woman to breast cancer, or a history of two or more breast biopsies for benign breast disease Additional factors can play a role in a woman's risk for breast cancer. Women age 45 or older who have at least 75 percent dense tissue on a mammogram are at some increased risk. A slight increase in risk for breast cancer is associated with having a first birth at age 30 or older. In addition, women who receive chest irradiation for conditions such as Hodgkin's disease at age 30 or younger, remain at higher risk for breast cancer throughout their lives. Not having any of the above risk factors does NOT mean that you are "safe." The majority of women who develop breast cancer do not have a family history of the disease, nor do they fall into any other special high-risk category. What Can You Do? If you are in your 40s or older, get a mammogram on a regular basis, every 1 to 2 years. Talk with your doctor or nurse about planning your personal schedule for screening mammograms and breast exams. Gather as much information as you can about your family history of cancer, breast cancer, and screening mammograms. Call the National Cancer Institute's Cancer Information Service for more information about breast cancer and mammograms at 1-800-4-CANCER (1-800-422-6237). People with TTY equipment, dial 1-800-332-8615. For the latest information on cancer, visit the National Cancer Institute's website for patients and the public at http://rex.nci.nih.gov or CancerNet at http://cancernet.nci.nih.gov. What Are the Benefits of Getting Mammograms? A mammogram can find breast cancer before a lump can be felt. A mammogram is the best method available today to detect breast cancer early. Early detection of the disease may allow more treatment options. What Are the Limitations*of Getting Mammograms? Mammograms may miss cancer that is present. Mammograms may find something that turns out NOT to be cancer. *These limitations occur more often in women under age 5

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