Drug Uses

Colchicine is used to treat attacks of gout.

How Taken

Take each dose of Colchicine with a full glass of water. You may take this medicine up to once every hour until the pain is relieved, until the maximum amount of medicine has been taken, or until nausea, vomiting, or diarrhea occurs. To prevent an attack from occurring, you may take Colchicine every day or several days a week. Do not take more doses than your doctor prescribed.

Warnings/Precautions

Do not take Colchicine without first talking to your doctor if you are breast-feeding a baby. Talk to your doctor if you are or plan on becoming pregnant as this medicine may have harmful effects on the unborn baby.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Possible Side Effects

Some of the side effects that may occur while taking Colchicine include: difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; fever; rash; numbness or tingling.

Storage

Store Colchicine at room temperature away from moisture and heat. Keep out of the reach of children.

Overdose

Symptoms of a colchicine overdose include nausea; vomiting; stomach pain; diarrhea; muscle weakness; burning in your throat, stomach, or skin; difficulty breathing; delirium; and seizures. An overdose of colchicine can result in death. If you suspect an overdose, seek immediate medical attention.

More Information

Tell your doctor and pharmacist about all medicines that you are taking. Colchicine may interact with other drugs.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.

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Colchicine, a water-soluble alkaloid found in the autumn crocus, blocks or suppresses cell division by inhibiting mitosis, the division of a cell's nucleus. Specifically, it inhibits the development of spindles as the nuclei are dividing. Normally, the cell would use its spindle fibers to line up its chromosomes, make a copy of them, and divide into two new cells with each daughter cell having a single set of chromosomes. With colchicine present, the spindle fibers don't form, and so the cell can't move its chromosomes around. The cell may end up copying some or all of the chromosomes anyway, but can't parcel them out into new cells, and so it never divides.
Because cancer cells divide much more rapidly than normal cells, cancers are more susceptible to being poisoned by mitotic inhibitors such as colchicine, paclitaxel, and the Vinca alkaloids.
However, colchicine has proven to have a fairly narrow range of effectiveness as a chemotherapy agent, so its only FDA-approved use is to treat gout (it is one of the active ingredients of ColBenemid, anti-gout tablets marketed by Merck & Co.), though it is also occasionally used in veterinary medicine to treat cancers in some animals. It is also used as an antimitotic agent in cancer research involving cell cultures.
Gout is an illness caused by faulty uric acid metabolism in which excess uric acid is turned into crystals of sodium urate, which are then deposited in the joints (most often in the big toe), causing inflammation and pain. Researchers aren't sure exactly how colchicine works against gout, but it does seem to reduce the frequency of severe attacks and relieves residual pain.
As far as side effects go, colchicine can cause a temporary reduction in the number of leukocytes (white blood cells) in the bloodstream; afterward, the leukocyte count can rebound to abnormally high levels. Colchicine also causes teratogenic birth defects in lab animals, and so pregnant women with gout should not use colchicine-containing drugs.
Colchicine poisoning resembles arsenic poisoning; the symptoms (which, because it is a mitotic poison, occur 2 to 5 hours after the toxic dose has been ingested) include burning in the mouth and throat, diarrhea, stomach pain, vomiting, and kidney failure. Death from respiratory failure often follows. A specific antidote doesn't exist, so treatment typically involves giving the victim activated charcoal or pumping the stomach.

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